Bulletins and Guides


Bulletin or Guide



COVID-19  swab collection instructions for medical practitioners
  • An infographic set of instructions for medical practitioners on the method of swab collection for COVID-19 and respiratory virus testing.
Allergy testing
  • Guide for the diagnosis of IgE-mediated allergy.
  • Includes standard and extended allergen panels, plus recombinant allergen testing for peanut allergy, mammalian meat allergy and wheat allergy.
AMH fertility test
  • The anti-Mullerian Hormone (AMH) is the best single pathology test available for assessing a woman's egg reserve.
  • AMH reference graph - AMH vs Age.
Biotin interference          
  • Taking high-dose biotin prior to blood collection may cause significant interference with some test results.
  • These are immune-based assays that use biotin-streptavidin in their matrix.
  • The majority of immunoassay tests performed at Sullivan Nicolaides Pathology are unaffected by high-dose biotin.
Blood and body fluid exposures - medical centre incidents
  • Anyone sustaining blood or body fluid exposure (BBFE) is at risk of acquiring a blood-borne viral infection such as HIV, HCV and HBV.
  • This provides information on the estimated risks of transmission.
  • Antibody testing, vaccination and follow-up.
Blood culture collections
  • Procedure for the collection of blood culture bottles.
BRCA1 and BRCA2 testing - Medicare update for doctors
  • Genetic testing of the genes responsible for familial breast or ovarian cancer is now rebated by Medicare.
  • This gives information on the MBS item numbers (73295, 73296, 73297) and the conditions that apply to them.
  • BRCA1 and BRCA2 are the genes most commonly implicated, but familial mutations in other genes such as STK11, PTEN, CDH1, PALB2, and TP53 can also cause familial breast cancer.
Cardiology Services
  • Information on the cardiology services offered by SNP
  • Ambulatory blood pressure monitoring
  • Holter monitoring
  • Resting electrocardiographs (ECGs)
Cervical screening test collection guide
  • ThinPrep® collection instructions for brush, spatula and broom-like devices.
  • ThinPrep® instructions for cervex sampler.
  • ThinPrep®, Pap test cytobrush/spatula protocol.
  • ThinPrep®, Pap Test Rovers®, Cervex-Brush®, Combi device protocol.
CST: National Cervical Screening Program February 2021 update
  • New guidelines for management of women at intermediate risk.
  • Revised recommendation that women who remain HPV positive at 12 months and have a negative pLSIL or LSIL reflex cytology, continue to be maanged as 'intermediate risk'.
  • Updated clinical pathways flowchart.
CFTR gene testing - Medicare update for doctors
  • Information about changes to the Medicare rebates for CFTR gene testing from January 2020.
CFTR gene testing - Flow chart for Medicare rebate
  • This leaflet outlines the clinical situations in which genetic testing for cystic fibrosis mutations is rebated by Medicare or requires a private payment.
Chlamydia and gonorrhoea testing: 
Self collections
  • Illustrated information for patient self-collection of chlamydia and gonorrhoea samples.
Critical Results Protocol
  • Critical values are those results that may indicate a life-threatening medical condition and require immediate notification to the referring doctor (irrespective of whether the pathology request was marked urgent).
  • If a result outside the critical limits is obtained, a scientist or pathologist will make every attempt to contact the referring doctor.
  • This guide lists critical results by laboratory department (biochemistry, haematology/coagulation, microbiology/molecular pathology, arterial gases).
Cutaneous squamous cell carcinoma
  • Diagnosis and management of cutaneous squamous cell carcinoma.
Dysplastic naevi - the controversy continues
  • The entity ‘mildly dysplastic naevus’ has been removed from the World Health Organisation’s classification of dysplastic naevi.
  • Dysplastic naevi are now to be graded as ‘low-grade dysplastic naevus’ (previous moderately dysplastic naevus) or ‘high-grade dysplastic naevus’ (previous severely dysplastic naevus).
  • Current data suggest no further treatment is necessary for dysplastic naevi with low-grade dysplasia (previous moderately dysplastic naevi) in which there are clear histologic margins and no pigment evident clinically (unless there was a high level of pre-biopsy clinical concern).
  • Re-excision with a 2-5mm clinical clearance is recommended for high-grade dysplastic naevi (previous severely dysplastic naevi) with involved histologic margins.
  • There is growing evidence that observation may be reasonable for low-grade dysplastic naevi (previous moderately dysplastic naevi) with histologically involved margins, if they were excised with clinically clear margins and no residual clinical pigment is observed. More data may be required before this is accepted into clinical practice.
  • There does not appear to be a clear consensus regarding whether high grade dysplastic (previous severely dysplastic) naevi require re-excision if completely excised with clear margins, albeit less than 2mm.
Enhanced liver fibrosis (ELF) score
  • An overview of three new non-invasive direct biomarkers of liver fibrosis (most commonly caused by chronic hepatitis B & C, alcohol abuse, and non-alcohol-related steatohepatitis or NASH).
  • Direct blood markers are products of activated hepatic stellate cells (myofibroblasts).
  • SNP uses a panel of the most promising markers, which are incorporated into a calculation, the Enhanced Liver Fibrosis (ELF) score. They are the N-terminal peptide of procollagen III (P3NP/PIIINP), hyaluronic acid and tissue inhibitor of matrix metalloproteinase 1 (TIMP-1).
Expanded reproductive carrier screening
  • An overview of expanded carrier screening including advantages of the test.
  • The disorders that are detected by testing.
  • Frequently asked questions and answers.
Familial hypercholesterolaemia
  • Genetic testing in patients with  familial hypercholesterolaemia.
  • Medicare-rebated testing from May 2020.
  • Testing and genetic counselling through your local Sonic Healthcare pathology practice.
Fine needle aspirate (FNA) preparation
  • Instructions on preparation for fine needle aspirates (FNA).
Genetic counselling with Sonic Genetics
  • Role of genetic counsellors.
  • Pre-test and post-test genetic counselling for complex genetic tests.
  • What can patients expect from genetic counselling?
  • How to arrange genetic counselling with Sonic Genetics.
Helicobacter pylori: Its new superbug status demands a paradigm shift in therapy 
  • Helicobacter pylori, the aetiological agent for some non-ulcer dyspepsia, peptic ulcer disease, gastric MALT lymphoma and gastric cancer has attained superbug status.
  • In February 2017, it was listed as a high priority organism by the World Health Organisation.
  • How has the situation arisen?
  • Some of the key points that have arisen from a re-examination of the guidelines.
HPV/CST patient self-collect testing
  • Sonic Healthcare now has an accredited facility for testing.
  • Criteria for offering the self-collected HPV testing.
  • Information on collecting the sample.
  • Screening pathway for self-collected samples.
How much human ringworm is zoophilic?A bulletin with focus on characterizing and comparing zoophilic with non-zoophilic dermatophyte human infections isolated at Sullivan Nicolaides Pathology (SNP) for the year 2013.2016-09-01
Investigating acute diarrhoea
  • Each Australian suffers on average about of foodborne diarrhoeal illness every five years.
  • This bulletin includes flowcharts that provide information to assists in identifying acute diarrhoea, therapies and testing options available.
  • Included is important information to consider when treating and testing for acute diarrhoea.
Lactose intolerance
and genetic testing
  • Lactose intolerance affects approximately 75% of the population.
  • Genetic testing can confirm lactose tolerance (also referred to as lactase persistence).
  • What causes lactose intolerance?
  • Who is affected by lactose intolerance?
  • Information for arranging a test.
Medicare criteria requirements
  • Most tests automatically qualify for a Medicare rebate, however for some tests, certain conditions apply. Some do not qualify for a rebate under any circumstances.
  • This provides information on the Medicare criteria applying to many of the tests. 
Merkel cell carcinoma
  • An update in our understanding of these rare and agressive tumours.
My Health Record pathology results upload
  • A guide for medical practitioners on pathology results upoad to My Health Record.
National Bowel Screening
Program - online with Sonic Dx
  • Information on how to access results from the National Bowel Screening Program via Sonic Dx.
NIPT: understanding an incomplete NIPT result
  • In 1-2% of women, the NIPT result is unable to provide an assessment. This is usually due to the complexity of pregnancy rather than a technical failure of the test.
Perfluorinated chemical testing - PFAS - PFOS
  • SNP is now testing for perfluoroalkyl substances including perfluorooctane sulphonate (PFOS) and perfluorooctanoic acid (PFOA).
  • This provides an overview of the compounds, sources of contamination and the local experience.
  • Also included is information on how to request testing.
Pharmacogenomics: personalise your patient's medication
  • Personalise your patient's medication according to their genetic variation: pharmacogenomic testing with the Sonic PGx Panel.
  • How to arrange PGx testing, information on report format and  list of medications available for guidance.
  • Single gene tests information.
Pharmacogenomics: understanding the PGx report
  • The Sonic PGx Panel checks for the presence of more than 60 significant variants in 10 genes involved in the metabolism of, or response to, more than 80 common medicatins.
  • Explanation of report format and content for improved understanding and interpretation.
Reproductive carrier screening
  • Reproductive carrier screening plays an important role in pre-pregnancy planning.
  • Sonic Genetics provides 2 testing options: a three-gene panel for common genetic disorders and the Beacon expanded carrier screen.
Rheumatic and connective tissue diseases
  • Investigations into rheumatic and connective tissue diseases.
  • Comments on antibodies. 
  • Other useful tests including lupus anticoagulant and anticardiolioin antibodies, HLA B27, complements,  anti-neutrophil cytoplasmic antibodies.
Souvenirs your skin brings home - cases from exotic places
  • In this bulletin, cases from exotic places are discussed including the cause, diagnosis and treatment.
Swab Guide 2020
  • General information and illustrations of commonly used swabs.
  • Which swab/s to use for what test, site or application.
  • Preparation and information on collection.
Trichophyton verrucosum - An uncommon zoophilic dermatophyte infection
  • A bulletin reviewing cases of T. verrucosum infection diagnosed at Sullivan Nicolaides Pathology (SNP) over the past 5 years(<2014).
Understanding reproductive carrier screening options
  • Quick reference guide for 2 types of reproductive carrier screening options.
  • Three-gene panel for common genetic disorders and the Beacon expanded reproductive carrier screen (>400 genes).
Understanding the melanoma report
  • Information on melanoma: incidence, risk factors, classifications, staging and treatment, and a glossary of the terms used in melanoma reports.
Understanding the skin pathology report
  • Information on normal skin structures, diagnoses, and a glossary of the commonly used terms in skin pathology reports.