Bulletins and Guides

 

Bulletin or Guide

Summary

Date

Anti-CCP (Cyclic citrullinated peptides)
  • Rheumatoid Arthritis (RA) and serologic markers.
  • Rheumatoid factor positive (IgM RF) is not an ideal test in the early detection of Rheumatoid Arthritis (RA).
  • The combination of Anti-CCP and RF tests is now considered to be the ‘gold standard’ in early detection of Rheumatoid Arthritis (RA).
  • This enables about 80% (i.e. 80% sensitivity) of RA patients to be detected in the early phase.
01-11-2017
BAP-oma (BAP-1 negative melanocytic tumour)
  • BAP-oma is a recently described melanocytic tumour, characterised by a mutation in the BAP-1 gene.
  • Patients with a germline mutation in BAP-1 are at increased risk of other tumours including cutaneous melanoma, uveal melanoma and mesothelioma.
  • BAP-1negative melanocytic lesions have distinct morphologic features, and BAP-1 loss can be demonstrated by immunohistochemistry.
01-01-2017
Biotin interference           
  • Taking high-dose biotin prior to blood collection may cause significant interference with some test results.
  • These are immune-based assays that use biotin-streptavidin in their matrix.
  • The majority of immunoassay tests performed at Sullivan Nicolaides Pathology are unaffected by high-dose biotin.
01-04-2018
Blood and body fluid exposures - medical centre incidents
  • Anyone sustaining blood or body fluid exposure (BBFE) is at risk of acquiring a blood borne viral infection such as HIV, HCV and HBV.
  • This provides information on the estimated risks of transmission.
  • Antibody testing, vaccination and follow-up.
01-05-2016
BRCA1 and BRCA2 testing - Medicare update for doctors
  • Genetic testing of the genes responsible for familial breast or ovarian cancer is now rebated by Medicare.
  • This gives information on the MBS item numbers (73295, 73296, 73297) and the conditions that apply to them.
  • BRCA1 and BRCA2 are the genes most commonly implicated, but familial mutations in other genes such as STK11, PTEN, CDH1, PALB2, and TP53 can also cause familial breast cancer.
01-05-2018
Cervical screening test collection guide
  • ThinPrep® collection instructions for brush, spatula and broom-like devices.
  • ThinPrep® instructions for cervex sampler.
  • ThinPrep®, Pap test cytobrush / spatula protocol.
  • ThinPrep®, Pap Test Rovers®, Cervex-Brush®, Combi device protocol.
01-12-2018
Critical results values    
  • Critical values are those results that may indicate a life threatening medical condition and require immediate notification to the referring doctor (irrespective of whether the pathology request was marked urgent).
  • If a result outside the critical limits is obtained, a scientist or pathologist will make every attempt to contact the referring doctor.
  • This guide lists critical results by laboratory department(biochemistry, Haematology/Coagulation, Microbiology/Molecular Pathology, Arterial gases).
01-10-2018
Dermatophytes: Focus on dermatophytes
  • Dermatophytes are a group of fungi capable of parasitising keratinised tissue such as skin, hair, and nails due to the presence of a unique enzyme keratinase.
  • This provides a comprehensive overview of testing, results, treatment and management.
01-02-2017
Enhanced liver fibrosis (ELF) score
  • An overview of three new non-invasive direct biomarkers of liver fibrosis (most commonly caused by chronic hepatitis B & C, alcohol abuse, and non-alcohol-related steatohepatitis or NASH).
  • Direct blood markers are products of activated hepatic stellate cells (myofibroblasts).
  • SNP uses a panel of the most promising markers, which are incorporated into a calculation, the Enhanced Liver Fibrosis (ELF) score. They are the N-terminal peptide of procollagen III (P3NP/PIIINP), hyaluronic acid and tissue inhibitor of matrix metalloproteinase 1 (TIMP-1).
01-01-2018
Fine needle aspirate (FNA) preparationInstructions on preparation for fine needle aspirate (FNA).01-10-2018
Guide to allergy testing
  • Allergic disorders result from an inappropriate, usually IgE-mediated, immune response upon exposure to either environmental or food allergens.
  • Common manifestations of allergy include rhinoconjunctivitis, asthma, eczema, acute urticaria and anaphylaxis. Disorders, such as chronic urticaria, hereditary angioedema and T-cell dermatitis (metal allergy), while clinically similar in some ways, are not IgE-mediated.
  • Allergic disease manifests in different ways through life and the likely causative agents can also change with age.
01-09-2018
Medicare Criteria requirements
  • Most tests automatically qualify for a Medicare rebate, however for some tests, certain conditions apply. Some do not qualify for a rebate under any circumstances.
  • This provides information on the Medicare criteria applying to many of the tests. 
01-03-2018
Medicare rule 3 exemptions
  • Under certain circumstances, Medicare Australia regulations allow a single signed request form to cover repeat testing.
  • This bulletin details the maximum number of repeat tests allowed.
  • Once the maximum number of tests has been reached, or six months have passed since the initial request, a new request form for repeat testing is required.
01-03-2018
Perfluorinated chemical testing - PFAS - PFOS
  • SNP is now testing for perfluoroalkyl substances including perfluorooctane sulphonate (PFOS) and perfluorooctanoic acid (PFOA).
  • This provides an overview of the compounds, sources of contamination and the local experience.
  • Also included is information on how to request testing.
01-06-2018
Testing for salmonella: A clean sweep of the broom
  • SNP has discontinued the Widal agglutination test for Salmonella typhi in the diagnosis of typhoid.
  • Two sets of blood cultures (for Salmonella Typhi and Salmonella Paratyphi)are the single-most useful diagnostic procedure for the diagnosis of enteric fever.
  • Other bodily fluids and tissues may yield positive cultures including faeces, urine, and if seeded, bones and joints, liver and gall bladder.
  • Information on what to request.
01-12-2017
Understanding the skin pathology report
  • Information on normal skin structures, diagnoses, and a glossary of the commonly used terms in skin pathology reports.
01-01-2018